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Sökning: WFRF:(Palli Domenico) > Chirlaque Maria Dolores > Olsen Anja > Refereegranskat > Pre-diagnostic C-re...

Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations

Nimptsch, Katharina (författare)
Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Aleksandrova, Krasimira (författare)
Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
Fedirko, Veronika (författare)
Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, TX, Houston, United States; Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
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Jenab, Mazda (författare)
International Agency for Research on Cancer (IARC-WHO), Lyon, France
Gunter, Marc J. (författare)
International Agency for Research on Cancer (IARC-WHO), Lyon, France
Siersema, Peter D. (författare)
Department of Gastroenterology and Hepatology, Radboud university medical center, Nijmegen, Netherlands
Wu, Kana (författare)
Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Katzke, Verena (författare)
Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Kaaks, Rudolf (författare)
Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Panico, Salvatore (författare)
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
Palli, Domenico (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy
May, Anne M (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Sieri, Sabina (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy
Bueno-de-Mesquita, Bas (författare)
Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, Netherlands
Standahl, Karina (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
Sánchez, Maria-Jose (författare)
Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
Perez-Cornago, Aurora (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Olsen, Anja (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Århus, Århus, Denmark
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Bonet, Catalina Bonet (författare)
Unit of Nutrition and Cancer, Catalan Institute of Oncology – ICO, Barcelona, Spain; Nutrition and Cancer Group, Bellvitge Biomedical Research Institute – IDIBELL, Barcelona, Spain; L’Hospitalet de Llobregat, Barcelona, Spain
Dahm, Christina C. (författare)
Department of Public Health, University of Århus, Århus, Denmark
Chirlaque, María-Dolores (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain
Fiano, Valentina (författare)
Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy
Tumino, Rosario (författare)
Cancer Registry and Histopathology Department Provincial Health Authority (ASP 7), Ragusa, Italy
Gurrea, Aurelio Barricarte (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Boutron-Ruault, Marie-Christine (författare)
Paris-Saclay University, UVSQ, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, Inserm, Villejuif, France
Menegaux, Florence (författare)
Paris-Saclay University, UVSQ, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, Inserm, Villejuif, France
Severi, Gianluca (författare)
Paris-Saclay University, UVSQ, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, Inserm, Villejuif, France; Department of Statistics, Computer Science and Applications “G. Parenti” (DISIA), University of Florence, Florence, Italy
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Lee, Young-Ae (författare)
Genetics of Allergic Disease Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Pediatric Allergy Experimental and Clinical Research Center, Charité Campus Buch, Berlin, Germany
Pischon, Tobias (författare)
Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Charité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin, Germany; Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Biobank Technology Platform, Berlin, Germany; Core Facility Biobank, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
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Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Department of Nutrition, Harvard TH. Chan School of Public Health, MA, Boston, United States Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany (creator_code:org_t)
2022-06-24
2022
Engelska.
Ingår i: BMC Cancer. - : BioMed Central (BMC). - 1471-2407 .- 1471-2407. ; 22:1
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.Methods: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression.Results: During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively).Conclusions: The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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